NCI Well Connect Mid-Week Brief
June 22, 2016
Dear Steve, 

DID YOU KNOW that a new study from the June issue of Current Biology suggests an intriguing strategy to boost memory for what you've just learned? Hit the gym four hours later. The findings show that physical exercise after learning improves memory and memory traces, but only if the exercise is done in a specific time window and not immediately after learning.

If you missed this in Monday's issue, please read Steve's Studies here.

Get our award-winning full-length eNewsletter, free analysis of 23andMe genetic results, access to our 42 title Action Plan library, and more!

Have a happy, healthy day. Steve and Bonnie
Lipids Suffer When Carbs Replace Fat
Bonnie and Steve: A worldwide analysis of how carbohydrate and fat intake affects blood lipid profiles in more than 100,000 individuals living in 19 low- to high-income countries suggests that the message to lower dietary saturated fats to lower cholesterol and thus decrease risk of cardiovascular disease is misleading. 

The danger lies in replacing saturated fat with carbohydrates, according to findings from research presented this month at the World Heart Federation's World Congress of Cardiology & Cardiovascular Health 2016.

Researchers discovered that a high-carbohydrate diet decreases your HDL cholesterol and increases your total cholesterol/HDL ratio. In addition, carbohydrates increase your apolipoprotein-B (apoB)/apoA ratio, which experts believe to be better markers to predict risk of cardiovascular disease. Finally, your triglycerides rise dramatically.

What the researchers suggest for those consuming too much saturated fat is to replace some of it with monounsaturated fatty acids (MUFAs), which had beneficial effects on lipid profiles.

What we love about this study is that the researchers emphasized that it is "very simplistic" to look at only one marker of blood lipids (they were referring to LDL). They emphatically stated that it is more complex than that.
Myriad Factors Impact Fertility
This article is usually reserved for NCI Well Connect Members. We are offering it to you free today as incentive to join at 40% OFF!


Steve and Bonnie:

Male Fertility
Traditionally, family planning and preconception care programs, research, and clinical management guidelines have focused almost exclusively on women. However, we need to acknowledge that men's reproductive health is just as important and should not be overlooked.

The goals are similar to those of women.

1. Effects on fertility and conception. When we talk about fertility and conception in general, we are thinking about factors that can affect sperm quality, quantity, concentration, and motility.

One of the main conclusions of a study in Physiological Reviews was that poor semen quality contributed to increases in infertility and the use of assisted reproductive technology. Among young men aged 20 to 25, 90% had abnormal sperm. It appears that we are at a tipping point in industrialized countries where poor semen quality is so widespread that it results in low pregnancy rates.

Certain health and surgical conditions, such as testicular conditions (eg, varicocele, history of testicular trauma, undescended testes, hypogonadism), diabetes, and erectile dysfunction may affect fertility to a certain degree.

Numerous medications (eg, nifedipine, spironolactone, steroids, testosterone, colchicine, selective serotonin reuptake inhibitors, cimetidine, tetracyclines) may alter the hypothalamic-pituitary-gonadal axis and may reduce male libido, contribute to erectile function, and have toxic effects on sperm.

Tobacco, alcohol, and certain drugs, such as marijuana and cocaine, can affect spermatogenesis.

Exposure to environmental hazards, such as radiation, heat, pollutants, lead, mercury, and other occupational chemicals, have been shown to affect sperm quality.

Hobby-related chemicals associated with woodworking, painting, pottery, stained glass, and gun cleaning may affect sperm production.

Stress has been shown to negatively affect sperm morphology and concentration.

Obesity: every 20 pounds that a man is above his ideal weight can lead to a 10% increase in the odds of infertility.

Several genetic disorders (for example, cystic fibrosis, Klinefelter syndrome, and polycystic kidney disease) may impair fertility and sperm quality.

A study in International Journal of Impotence Research suggest the damage not only affects men's ability to conceive, but negatively affects the genes passed to their children. A study from Cell Metabolism showed that sperm cells in lean and obese men, respectively, possess different epigenetic marks that alter the next generation's appetite.

2. Effects on pregnancy or maternal health. Male lifestyle factors can affect the female partner and the pregnancy. Primarily, we are talking about smoking, which exposes the expectant mother to secondhand smoke and potentially has negative effects on the fetus.

Father's involvement during pregnancy and delivery can have a positive effect on the health outcomes of not only the man, but also his partner and their children.

3. Advanced paternal age and conditions, such as autism, schizophrenia, and other mental health issues have been linked in recent research.

4. Dietary choices are crucial. For example, a new study in The Journal of Nutrition found that the consumption of fruit and vegetables with low-to-moderate pesticide residues was positively related to sperm counts in young men unselected by fertility status. This suggests that pesticide residues may modify the beneficial effects of fruit and vegetable intake on semen quality.

Female Fertility
While we are guilty for mostly focus on female fertility, in this update, there is little to report, except that exercise is good, but too much, as in women who are endurance-distance athletes, can hinder fertility. According to a study in Fertility and Sterility, lean women who reduce their physical activity from vigorous to moderate may also improve their fertility.

How Fertility Can Be Affected by Female Reproductive Anatomy :
  • Hypothalamus makes a hormone GnRH which instructs the pituitary to make two key fertility chemicals, FSH and LH.
  • Thyroid levels too high or low can make it tough to get pregnant.
  • Adrenal glands release cortisol, which in excessive amounts may disrupt ovulation.
  • Pancreas makes insulin. When levels get too high (excess carbs/sugars), ovulation may be disrupted.
  • Fat cells secrete estrogen (why women need a certain amount of body fat to get pregnant).
  • Ovaries produce eggs, as well as progesterone (the pregnancy hormone), which impacts everything from menstruation to bone strength and heart health.
  • Fallopian tubes connect the ovaries to the uterus. Where eggs meet the sperm.
  • Uterus provides a nurturing, protective environment for a fertilized egg to grow into a fetus.
  • If your period is longer than 25 to 30 days, you may not be ovulating regularly. Menstrual cycles lasting less than 25 days  are a red flag as well.
Genetic Nutrient Deficiency Testing

Bonnie and Steve: If one or more of these boxes are yellow or red, then you have genetic deficiencies that may impair your ability to break down and move toxins from your body, as well as absorb vitamins A & D. The great thing is that you can prevent impairment with diet, lifestyle, and nutrient modification.

For example, if you cannot adequately convert Beta Carotene from food into absorbable vitamin A (retinol), this greatly increases your risk for the eye disease Macular Degeneration. Food and supplement modification addresses this issue.

The graphic on top is the methylation cycle. The bottom graphic is genes associated with vitamins A & D. If you have not done your 23andMe genetic test, yet, what are you waiting for?

UP4 Acidophilus Discontinued

Bonnie and Steve: Much to our chagrin, UAS Life Sciences has discontinued UP4 Acidophilus (yellow label). Their reasoning was: "it's not a big seller" and "customers want multiple strains per capsule".

When we mentioned that in many instances, those who suffer from yeast imbalances need and can only tolerate acidophilus, they had no credible response. The cold reality is that even supplement manufacturers go with what sells, not what serves the best interest of its diverse customers.

Luckily, we have options to cater to your individual needs.
  1. If you no longer struggle with yeast imbalance, you can switch to UP4 Daily(lactobacillus acidophilus and bifidus).
  2. For everyone else, we contract manufactured our own Acidophilus product: Well Probiotic L. Acidophilus. We will ship this product with refrigeration during the warmer months. but you can store it exactly as you did with UP4 Acidophilus (just refrigerate after opening).
We have never been about "what sells". Unfortunately, we are penalized for this as evidenced by the discontinuation of certain Twinlab products and now this.

We will continue to focus solely on what's best for your individual needs, as well as our own, because everyone here, in addition to our friends and families, all use the same products you do!
NCI Well Connect Membership
40% OFF
One Year Membership Includes:
  1. Weekly eNewsletters (84 issues). We publish our long-form issue on Monday and a Mid-Week Brief on Wednesday. Here is a recent preview issue.
  2. Self-Help Action Plans. Access to two titles per month from our self-help Action Plan Library. There are currently 42 Action Plan titles to date on all aspects of wellness, including the new Eye-Mazing Vision Protection Action Plan. You can view the full library of titles here.
  3. Natural Foods Shopping List. Updated quarterly, our Natural Foods Shopping List includes only the most meticulously vetted, highest quality food and beverage products that we recommend to our clients. These include gluten-free, corn-free, and kosher pareve items.
  4. Free 15 Minute Wellness Coaching Sessions Including 23andMe/Pure Genomics Analysis (visits with Bonnie are separate). Topics include Genetics, Immune System, Detox, Shedding Weight, Food Cravings and Food Addiction, or those of your own choosing.

The approximate cost for all of this? Less than one dollar a week!


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We appreciate your continued patronage and support.

Have a happy, healthy day,
Bonnie, Steve, Carolyn, Lilo, Elizabeth, and Jeannie
(847) 498 3422

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